Last edited by Mik
Tuesday, July 28, 2020 | History

6 edition of Mechanisms of Hepatocyte Injury and Death (Falk Symposium) found in the catalog.

Mechanisms of Hepatocyte Injury and Death (Falk Symposium)

  • 373 Want to read
  • 11 Currently reading

Published by Springer .
Written in English

    Subjects:
  • Hepatology,
  • Medical / Nursing,
  • Gastroenterology,
  • Diseases Of The Liver And Biliary Tract,
  • Medical,
  • Liver cells,
  • Internal Medicine,
  • Medical / Internal Medicine,
  • Necrosis,
  • Congresses,
  • Diseases,
  • Liver

  • Edition Notes

    ContributionsD. Keppler (Editor), H. Popper (Editor), L. Bianchi (Editor), W. Reutter (Editor)
    The Physical Object
    FormatHardcover
    Number of Pages432
    ID Numbers
    Open LibraryOL8280279M
    ISBN 100852008538
    ISBN 109780852008539

    Two mechanisms— apoptosis and necrosis—can contribute to hepatocyte death. In apoptosis, the affected cell actively participates in the cell death process, whereas in necrosis the cell death occurs in response to adverse conditions in the cell’s environment. Numerous factors that may con-tribute to the initiation of hepatocyte apoptosis areFile Size: 70KB. Cellular Injury in Liver Diseases (Cell Death in Biology and Diseases) [Ding, Wen-Xing, Yin, Xiao-Ming] on *FREE* shipping on qualifying offers. Cellular Injury in Liver Diseases (Cell Death in Biology and Diseases) the chapters of this volume describe drug and virus-mediated hepatocyte injury, alcohol, lipid and bile acid Format: Hardcover.

    @article{osti_, title = {Bax-mediated mitochondrial outer membrane permeabilization (MOMP), distinct from the mitochondrial permeability transition, is a key mechanism in diclofenac-induced hepatocyte injury: Multiple protective roles of cyclosporin A}, author = {Siu, W P and Pun, Pamela Boon Li and Latchoumycandane, Calivarathan and. KOFF,M.D. precise steps that result in hepatocyte injury and death Metro West Medical Center remain speculative. Hepatic injury through lipid peroxFramingham, Massachusetts 01 idation, the oxidation of protein thiols or the covalent binding of electrophilic metabolites to macromolecules is not a .

    As TNFα-mediated hepatocyte death is also important for acute liver injury, JNK is considered to be a promising therapeutic target for acute liver injury. In fact, SP and another JNK inhibitor D-JNKi, which is a peptide inhibitor of JNK, exert protective effects on LPS/GalN-induced fulminant hepatitis [ 44, Cited by: 1 8 CHAPTER 1 Cell Injury, Cell Death, and Adaptations Reversible Injury The two main morphologic correlates of reversible cell injury are cellular swelling and fatty change. Cellular swelling is the result of failure of energy-dependent ion pumps in the plasma membrane, leading to an inability to maintain ionic and fluid homeostasis.


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Mechanisms of Hepatocyte Injury and Death (Falk Symposium) Download PDF EPUB FB2

Mechanisms of Hepatocyte Injury and Death: Falk Symposium 38 Article (PDF Available) in Journal of the Royal Society of Medicine 79(1) January with 13 Reads How we measure 'reads'Author: John Timbrell. Hepatocytes are the most numerous cell type in the liver, and their apoptosis is prominent in liver injury.

3 – 5 Councilman bodies, described by the pathologist William T. Councilman ( – ), in the liver of patients with yellow fever result from apoptotic death of individual hepatocytes.

6 Cited by:   Introduction. Acetaminophen (APAP; paracetamol) is widely used as an analgesic and antipyretic drug. At therapeutic doses, it is considered effective and safe but an overdose can cause severe liver injury, liver failure and even death (Larson, ).Currently, APAP is the leading cause of drug-induced liver failure in the US and UK ().Considerable progress has been made in the Cited by: Bile acids cause liver injury during cholestasis by inducing hepatocyte apoptosis by both Fas-dependent and -independent mechanisms.

However, the Fas-independent apoptosis also appears to be death. Death of constituent cell populations of the liver is a central component of liver injury cascades. Cell death in the liver can occur via regulated (apoptosis or necroptosis) or unregulated (necrosis) by: 4.

Get this from a library. Mechanisms of hepatocyte injury and death: proceedings of the 38th Falk Symposium, held during Basel Liver Week, Basel, October[D Keppler;]. T1 - Mechanisms of Liver Injury. AU - Malhi, Harmeet. AU - Gores, Gregory J. PY - /10/ Y1 - /10/ N2 - The death of constituent cell populations of the liver is a central component of liver injury cascades.

Hepatocytes are targeted by most injurious stimuli, Cited by: 4. Novel mechanism of fetal hepatocyte injury in congenital alloimmune hepatitis involves the terminal interaction of specific alloimmune IgG with the fetal liver results in hepatocyte injury and death.

an immune mechanism is thought to be involved. 29 Possible mechanisms in the others include failure to clear MAC by hepatocytes as a Cited by: @article{osti_, title = {Mechanisms of acetaminophen-induced cell death in primary human hepatocytes}, author = {Xie, Yuchao and McGill, Mitchell R.

and Dorko, Kenneth and Kumer, Sean C. and Schmitt, Timothy M. and Forster, Jameson and Jaeschke, Hartmut}, abstractNote = {Acetaminophen (APAP) overdose is the most prevalent cause of drug-induced liver injury in western countries. The Lancet Occasional Survey PATTERNS OF HEPATOCYTE INJURY IN MAN Sheila Sherlock Department of Medicine, Royal Free Hospital School of Medicine, Pond Street, London NW3 2QG, United Kingdon Three patterns of hepatocyte injury in man, direct, immunological, and cholestatic, are by: T1 - Novel mechanism of fetal hepatocyte injury in congenital alloimmune hepatitis involves the terminal complement cascade.

AU - Pan, Xiaomin. AU - Kelly, Susan. AU - Melin-Aldana, Hector. AU - Malladi, Padmini. AU - Whitington, Peter F. PY - /6/1. Y1 - /6/1Cited by: The hepatocyte on the left is also blebbed, but the plasma membrane is still intact, and viability has not yet been lost.

Bar is 5 μm. Adapted with permission from Herman B, Nieminen AL, Gores GJ, Lemasters JJ. Irreversible injury in anoxic hepatocytes precipitated by an abrupt increase in plasma membrane permeability. FASEB J ;–Cited by: Evidence suggests that most neonatal hemochromatosis (NH) is the phenotypic expression of gestational alloimmune fetal liver injury.

Gestational alloimmune diseases are induced by the placental passage of specific reactive immunoglobulin G and often involve the activation of fetal complement by the classical pathway leading to the formation of membrane attack complex (MAC) as the effector of Cited by:   Abstract.

A diverse range of pathophysiologic processes lead to liver injury in the pediatric population. This chapter discusses mechanisms of hepatocyte or other liver cellular injury, beginning with a brief discussion of liver functions and general mechanisms of cell : Kimberly J.

Riehle, Nelson Fausto. Although both hepatocyte cell injury and inflammation occur in this disease process, the cellular and molecular mechanisms linking hepatocyte injury to inflammation remain unclear.

Although multiple cell types contribute to hepatic inflammation in NASH, the predominant cell types appear to Cited by: 1. Tests of Hepatocellular Injury. With hepatocyte cell death, the intracellular enzymes leak out, causing an elevation in their serum levels.

The common tests of this group include aspartate aminotransaminases (AST), and alanine aminotransferase (ALT). Tests of Cholestatic Injury. An impairment in bile flow leads to cholestasis (literally, static.

Europe PMC is an ELIXIR Core Data Resource Learn more >. Europe PMC is a service of the Europe PMC Funders' Group, in partnership with the European Bioinformatics Institute; and in cooperation with the National Center for Biotechnology Information at the U.S.

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The hepatocyte is especially vulnerable to injury due to its central role in xenobiotic metabolism including drugs and alcohol, participation in lipid and fatty acid metabolism, its unique role in the enterohepatic circulation of bile acids, the widespread prevalence of hepatotropic viruses, and its existence within a milieu of innate immune responding by: Buy Cellular Injury in Liver Diseases (Cell Death in Biology and Diseases): Read Books Reviews - ce: $ Cellular mechanisms of hepatic injury and fibrosis due to hepatocyte apoptosis.

Hepatocyte apoptosis results in the formation of apoptotic bodies. Engulfment of apoptotic bodies by liver resident macrophages or Kupffer cells enhances their expression of death ligands such Cited by:.

Nucleic Acid damage can be the result Free Radical Cell Injury or due to the activation of nucleases following increases in cytosolic calcium. Effects of Damage; Significant damage to the DNA genome generally activates mechanisms of apoptosis which end in programmed cell death.This book, along with its companion volume, Molecules, Systems and Signaling in Hepatic Cell Death, provides a thorough and comprehensive discussion on the topic of cell death and liver disease.

Cellular Injury in Liver Diseases is an essential addition to the Cell Death in Biology and Diseases series and will appeal to scientists, clinicians.Hepatotoxicity and drug-induced liver injury also account for a substantial number of compound failures, highlighting the need for toxicity prediction models (e.g.

DTI), and drug screening assays, such as stem cell-derived hepatocyte-like cells, that are capable of detecting toxicity early Specialty: Gastroenterology.